About the course

Are you a parent or clinician interested in understanding the critical role mitochondria play in brain development and neurological function? This on-demand course offers a unique opportunity to learn directly from Richard E. Frye, MD, PhD, a child neurologist and leading researcher who has spent decades studying metabolic and mitochondrial dysfunction in neurodevelopmental disorders. This course explores how mitochondrial health influences brain development, cognitive function, and the risk for neurodevelopmental conditions.

About the Creator

Dr. Richard Frye is a Child Neurologist specializing in neurodevelopmental and neurometabolic disorders. He holds an MD and PhD from Georgetown University, completed residencies and fellowships at Harvard and Boston University, and is board-certified in Pediatrics and Neurology with Special Competence in Child Neurology. A national leader in autism research, Dr. Frye has authored over 300 peer-reviewed publications and led multiple clinical trials investigating metabolic and physiological treatments for ASD, including folinic acid. His current research focuses on metabolic endophenotypes and targeted therapies for ASD. In 2022, he co-founded The Autism Discovery and Treatment Foundation and continues to see patients in the U.S. and internationally.

Curriculum

12 Chapters · 12 Lessons

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      Introduction

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      Important Basic Functions of Mitochondria

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      Electron Transport Chain and ROS Generation

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      Neurological and Neurodevelopmental

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      Key Prenatal Phases of Human Brain Development

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      Neurodevelopmental Stage Consequences of Mitochondrial Dysfunction

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      Mitochondrial Function in Cortical Patterning and Proliferation

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      Mitochondrial Function in Synaptogenesis and Synaptic Pruning

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      Neurological Function Consequences of Mitochondrial Dysfunction

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      Mitochondria are Essential at the Presynaptic Button

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      Mitochondria are Needed for Active Neurons with High Firing Rates

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      Neurotransmitter Reuptake and the Glutamate-GABA Cycle